论文部分内容阅读
目的:研究DNA依赖蛋白激酶(DNA-PK)在人喉鳞状细胞癌(LSCC)及正常喉黏膜组织中的表达,探讨其与LSCC临床病理特征之间的关系。方法:应用免疫组织化学方法(Envision)检测64例LSCC组织(实验组)及15例正常喉黏膜组织(对照组)中DNA-PK的表达水平,结合LSCC的临床病理特征进行分析。结果:DNA-PK在对照组和实验组中的阳性表达率分别为26.67%(4/15)、78.13%(50/64),差异有统计学意义(P<0.05)。DNA-PK表达与LSCC的组织分化程度相关(P<0.05),与临床分期、淋巴结转移无明显相关(P>0.05)。结论:DNA-PK的表达与LSCC的病变发展有关。
Objective: To investigate the expression of DNA-dependent protein kinase (DNA-PK) in human laryngeal squamous cell carcinoma (LSCC) and normal laryngeal mucosa, and to explore its relationship with clinicopathological features of LSCC. Methods: The expression of DNA-PK in 64 cases of LSCC (experimental group) and 15 cases of normal laryngeal mucosa (control group) was detected by immunohistochemistry (Envision), and the clinicopathological features of LSCC were analyzed. Results: The positive rates of DNA-PK in control group and experimental group were 26.67% (4/15) and 78.13% (50/64), respectively. The difference was statistically significant (P <0.05). The expression of DNA-PK was correlated with the degree of tissue differentiation of LSCC (P <0.05), but not with clinical stage and lymph node metastasis (P> 0.05). Conclusion: The expression of DNA-PK is related to the development of lesions in LSCC.