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目的探讨血清中AFP、GP73、GPC3三种肿瘤标志物在肝细胞癌(hepatocellular carcinoma,HCC)中的诊断价值及联合检测的意义。方法检测了45例HCC患者、32例乙肝携带者和30例正常体检者血清中AFP、GP73、GPC3的含量并进行相关分析。结果 AFP、GP73、GPC3用于诊断HCC时的敏感度和特异度分别是57.8%和90.6%、80.0%和98.3%、31.1%和92.3%,ROC曲线下面积分别为0.874、0.963、0.507;AFP与GP73联合,AFP与GPC3联合,GP73与GPC3联合以及三种标志物联合时敏感度和特异度分别是93.9%和88.9%、73.3%和83.8%、84.4%和91.5%、95.6%和82.1%,ROC曲线下面积分别为0.976、0.821、0.963、0.976。结论联合检测血清中AFP和GP73对HCC的诊断具有重要价值,血清GPC3检测对HCC的诊断意义较小。
Objective To investigate the value of serum AFP, GP73 and GPC3 in the diagnosis of hepatocellular carcinoma (HCC) and its significance. Methods The serum levels of AFP, GP73 and GPC3 in 45 HCC patients, 32 HBV carriers and 30 normal controls were detected and correlated. Results The sensitivity and specificity of AFP, GP73 and GPC3 for the diagnosis of HCC were 57.8% and 90.6%, 80.0% and 98.3%, 31.1% and 92.3%, respectively. The areas under the ROC curve were 0.874, 0.963 and 0.507, respectively. In combination with GP73, the sensitivity and specificity of AFP in combination with GPC3, GP73 in combination with GPC3, and the three markers were 93.9% and 88.9%, 73.3% and 83.8%, 84.4% and 91.5%, 95.6% and 82.1%, respectively , The areas under the ROC curve were 0.976, 0.821, 0.963, 0.976 respectively. Conclusion Combined detection of AFP and GP73 in serum is of great value in the diagnosis of HCC. The detection of serum GPC3 has little significance in the diagnosis of HCC.