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目的：研究黄颜木素对激活的永生型大鼠肝储脂细胞——ＨＳＣ－Ｔ６细胞增殖和胶原合成的影响。方法：细胞增殖采用结晶紫染色法检测，胶原合成采用３Ｈ－脯氨酸掺入法分析。结果：黄颜木素（６．２５～５０．００μｍｏｌ／Ｌ）以剂量依赖方式显著抑制血小板源生长因子（ＰＤＧＦ）刺激的ＨＳＣ－Ｔ６细胞增殖，并抑制转化生长因子β１（ＴＧＦβ１）诱导的细胞内胶原合成。结论：黄颜木素具有抑制激活的肝储脂细胞增殖和胶原合成的作用。
OBJECTIVE: To study the effects of xanthogenin on the proliferation and collagen synthesis of activated rat liver lipid-storing cells, HSC-T6 cells. Methods: Cell proliferation was detected by crystal violet staining, and collagen synthesis was analyzed by 3H-proline incorporation. RESULTS: Dangyanin (6.25-50.00 μmol/L) significantly inhibited platelet-derived growth factor (PDGF)-stimulated proliferation of HSC-T6 cells and inhibited transforming growth factor β1 (TGFβ1)-induced intracellular collagen in a dose-dependent manner. synthesis. CONCLUSION: Dicyanol has the effect of inhibiting the activation of liver cell proliferation and collagen synthesis.