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自1975年Hughes等发现和确定脑内存有内源性类吗啡样物质——甲硫氨酸脑啡肽Met-Enkephalin(和亮氨酸脑啡肽)Leu-Enkephalin)两个五肽以来,很快引起了各有关学科和广大科学工作者的重视,对这类物质进行了较广泛深入的研究,发展很快,它涉及到生理、生化、药理、临床等学科,有人曾从不同角度对这一问题作过综述报告,这里仅就该类物质对中枢神经系统(CNS)影响的一些资料作一概略介绍。由吗啡镇痛到脑内刺激产生镇痛(SPA)
Since Hughes and other found in 1975 and found that the brain has stored the endogenous morphine-like substance - methionine enkephalin Met-Enkephalin (and Leu-Enkephalin) Leu-Enkephalin two pentapeptides since Quickly aroused the attention of all the relevant disciplines and the majority of scientists, carried out a more extensive and in-depth study of such materials, and developed rapidly. It involved disciplines such as physiology, biochemistry, pharmacology and clinical science. Someone once did this from different angles A summary report on the issue, here only on the type of substance on the central nervous system (CNS) some information on a brief introduction. Pain relief from morphine to brain stimulation (SPA)