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(一)药物动力学丙戊酸钠(VPA)口服后几乎全部迅速吸收,1～4小时血浆浓度达高峰,与食物同时服吸收速度减慢,但总吸收量不变.直肠给药与口服的生物利用度无差异.每日剂量和血浆药物浓度之间的关系个体差异很大,这种差异可能是由于吸收、生物转化和排泄的不同.VPA在人体与血浆旦白结合率很高,可达90～95%,随温度上升结合率下降,药物的蛋白结合率有一定限度,
(A) Pharmacokinetic Sodium valproate (VPA) almost all absorbed rapidly after oral administration, 1 to 4 hours peak plasma concentration, and food taken simultaneously slow down the absorption rate, but the total absorption unchanged. Rectal administration and oral There is no difference between the bioavailability of daily dose and plasma drug concentration relationship between individuals vary widely, this difference may be due to absorption, bioconversion and excretion of different.VPA in the human body and plasma protein binding rate is high, Up to 90 ~ 95%, with the rise in the binding rate decreased, the protein binding rate of the drug has a certain limit,