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目的:研究温阳益气化饮法对慢阻肺(COPD)稳定期生活质量的影响。方法:稳定期COPD患者共60例随机分成中药治疗组和西医对照组,对照组按指南方案给予常规治疗,中药治疗组在对照组治疗的基础上加用干姜、淫羊藿、茯苓、甘草、五味子煎汤并冲服补中益气颗粒,疗程3个月,评价两组患者干预效果及安全性。结果:两组相比临床疗效及中医证候指标评分治疗组优于对照组(P<0.05或P<0.01);两组急性发作次数均减少(P<0.05),不过无明显差异;治疗组FEV1、FEV1%及FEV1/FVC虽较前有上升但差异无显著性(P>0.05),FEV1/FVC值两组间差异具有统计学意义(P<0.05)。生存质量评分除F2S、F3S下降不明显外两组均有改善(P<0.05或P<0.01),两组差值比较除F2S外均有统计学意义(P<0.05或P<0.01);两组均未见不良反应。结论:温阳益气化饮能较好控制慢阻肺患者稳定期病情,改善COPD患者肺功能及中医证候,改善生活质量并减少发作次数,用药安全且依从性较好。
Objective: To study the effect of warming Yang and invigorating Qi and drinking method on the quality of life in chronic obstructive pulmonary disease (COPD). Methods: A total of 60 stable COPD patients were randomly divided into traditional Chinese medicine treatment group and western medicine control group. The control group was given routine treatment according to the guideline program. On the basis of the control group, the traditional Chinese medicine treatment group added ginger, epimedium, tuckahoe, , Schisandra Decoction and Buzhong Buqi Yiqi particles, three months of treatment, evaluation of two groups of patients with intervention effects and safety. Results: Compared with the control group (P <0.05 or P <0.01), the number of acute attacks in both groups decreased (P <0.05), but there was no significant difference between the two groups; the treatment group The FEV1, FEV1% and FEV1 / FVC had no significant difference between before and after treatment (P> 0.05). There was significant difference between the two groups in FEV1 / FVC (P <0.05). The quality of life scores were significantly improved except F2S and F3S (P <0.05 or P <0.01), except for F2S (P <0.05 or P <0.01); Group had no adverse reactions. Conclusion: Warming Yang Yi Qi Hua Yin can better control COPD patients’ stable condition, improve pulmonary function and TCM syndromes, improve quality of life and reduce the number of seizures in patients with COPD. The medication is safe and has good compliance.