目的 :探讨控制原发灶在头颈部粘膜恶性黑色素瘤治疗中的作用。方法 :回顾分析本院 196 5～ 1993年收治的头颈部粘膜恶性黑色素瘤病人 77例 ,比较原发灶控制与否与远处转移和 5年生存率的关系。结果 :原发灶控制与未控制者远处转移率分别为 2 5 .9%、70 % ;5年生存率分别为 74.1%、2 .0 % (P <0 .0 1)。结论 :积极控制原发灶将改善头颈部粘膜恶性黑色素瘤的预后。 Objective : To explore the role of controlling primary lesions in the treatment of malignant melanoma of head and neck mucosa. METHODS: A retrospective analysis of 77 cases of head and neck mucosal melanoma treated in our hospital from 196 5 to 1993 was performed to compare the control of the primary tumor with distant metastases and 5-year survival. Results: The distant metastatic rates of control and uncontrolled persons were 25.9% and 70%, respectively; the 5-year survival rates were 74.1% and 2.0%, respectively (P < 0.01). Conclusion: Active control of primary lesions will improve the prognosis of head and neck mucosal melanoma.