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我们用青岛制药厂生产的新H_2受体阻滞剂法莫替丁在北京、沈阳、大连、锦州和青岛等七家医院进行了治疗消化性溃疡的多中心临床研究。300例患者服用法莫替丁20mg一天二次共6周,并用甲氰味呱400mg一天一次共6周进行对照(179)。分双盲摸拟和开放两组进行。结果表明法莫替丁在治疗消化溃疡方面疗效与甲氰味呱相似。双盲组中愈合率分别为89.6％与80％(P>0.05),总有效率分别为95.8％与91％(P>0.05)。开放组中法莫替丁愈合率为86.9％,甲氰咪呱组为65％,两组比较P值<0.05。两组的总有效率为96.8％与92.4％(P>0.05)。结果同时表明法莫替丁对十二指肠溃疡和胃溃疡的疗效相似(愈合率为87.5％与86.8％,P>0.05)。未发现法莫替丁组有明显副作用,我们认为,法莫替丁是一种新的、强效的、作用时长的H_2受体阻滞剂,病人易耐受,副作用小,且无抗雄性激素的副作用。
We used a new H 2 receptor blocker produced in Qingdao Pharmaceutical Factory, famotidine in seven hospitals in Beijing, Shenyang, Dalian, Jinzhou and Qingdao for the treatment of peptic ulcer in a multicenter clinical study. 300 patients took famotidine 20 mg twice a day for 6 weeks and control group (600 mg) with cimetidine 400 mg once daily for 6 weeks (179). Sub-double-blind simulation and open two groups. The results show that famotidine in the treatment of peptic ulcer efficacy and cyanide Gui similar. In the double-blind group, the healing rates were 89.6% and 80% respectively (P> 0.05), and the total effective rates were 95.8% and 91% respectively (P> 0.05). In the open group, the rate of famotidine healing was 86.9% and that of the cimetidine group was 65%. The P values of the two groups were less than 0.05. The total effective rate was 96.8% in both groups and 92.4% (P> 0.05). The results also showed that famotidine had similar effects on duodenal ulcer and gastric ulcer (healing rates 87.5% and 86.8%, P> 0.05). Famotidine was not found to have significant side effects, and we believe that famotidine is a new, potent, long-acting H-2 blocker that is easily tolerated, has fewer side effects and is not anti-male Hormonal side effects.