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生长抑素(somatostatin,SS)是一种广泛存在于中枢神经系统、胃肠道和胰腺组织内的,具有广泛抑制作用的胃肠激素。SS能通过直接和间接途径抑制肿瘤的生长,其抑制作用是通过应答细胞膜上特异性的生长抑素受体(somatostatin receptor,SSR)介导的。SSR有1~5五种亚型,在不同的种属和组织中分布与表达的亚型及量均不同。人大肠癌细胞有SSR分布表达,,但迄今为止,在大肠癌中分布与表达的与其发生、发展密切相关的SSR亚型及SS通过SSR调控大肠癌生长的具体机制尚不十分清楚。
Somatostatin (SS) is a gastrointestinal hormone that has extensive inhibitory effects in the central nervous system, gastrointestinal tract and pancreatic tissues. SS can directly and indirectly inhibit the growth of tumor by inhibiting the somatostatin receptor (SSR) on the cell membrane. There are 1 to 5 SSR subtypes in SSR, which are distributed and expressed in different species and tissues in different subtypes and quantities. Human colorectal cancer cells have SSR distribution, but so far, the specific mechanism of distribution and expression of SSR subtypes and their occurrence and development in colorectal cancer, which regulate the growth of colorectal cancer by SSR, is not yet clear.