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采用巨细胞病毒(CMV)单克隆抗体对44例肾移植患者外周血白细胞进行了CMV抗原检测,同时进行了血清学ELISA检测和临床症状观察。结果显示:28例活动性CMV感染患者中,26例抗原检测阳性;16例无活动性CMV感染患者中,仅1例抗原检测阳性;抗原阳性白细胞数与CMV特异性的临床症状相一致。认为单克隆抗体检测外周血白细胞中CMV抗原的方法是早期、快速诊断活动性CMV感染的较理想方法。
Cytomegalovirus (CMV) monoclonal antibody was used to detect the CMV antigen in 44 patients with renal allograft and serological ELISA and clinical symptom were also performed. The results showed that of the 28 patients with active CMV infection, 26 were positive for antigens. Only 1 of the 16 patients with active CMV infection was positive for antigens. The number of antigen-positive leukocytes was consistent with the CMV-specific clinical symptoms. The idea that monoclonal antibodies detect CMV antigens in peripheral white blood cells is an ideal method for early diagnosis of active CMV infection.