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目的观察高血压伴有阵发性心房颤动(AF)的患者应用缬沙坦在AF复律后维持窦性心律的疗效。方法选择2006年2月至2007年8月北京同仁医院心血管中心73例高血压伴有阵发性AF患者,AF转复后随机分为2组,在口服胺碘酮的基础上,对照组36例给予常规降压药物(除外ACEI和ARB类药物),治疗组37例给予包括缬沙坦的降压药物,疗程观察18个月。结果治疗组左房内径明显小于对照组,窦性心律维持率明显高于对照组,结果差异有统计学意义。结论胺碘酮联合应用缬沙坦治疗高血压伴阵发性AF,可在降低血压的同时,有效维持窦性心律。
Objective To observe the effect of valsartan in maintaining sinus rhythm after AF cardioversion in patients with hypertension and paroxysmal atrial fibrillation (AF). Methods From February 2006 to August 2007, Beijing Tongren Hospital Cardiovascular Center, 73 patients with hypertension complicated with paroxysmal AF were randomly divided into 2 groups after AF conversion. On the basis of oral administration of amiodarone, the control group 36 patients were given conventional antihypertensive drugs (except ACEI and ARB drugs), and 37 patients in the treatment group were given antihypertensive drugs including valsartan. The course of treatment was observed for 18 months. Results The diameter of the left atrium was significantly smaller in the treatment group than in the control group, and the maintenance rate of sinus rhythm was significantly higher than that of the control group. The difference was statistically significant. Conclusions Amiodarone combined with valsartan in the treatment of hypertension complicated with paroxysmal AF can reduce the blood pressure and maintain the sinus rhythm effectively.