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目的 :探讨慢性鼻窦炎局部粘膜中免疫活性细胞和分泌免疫成分在防御炎症过程中的作用。方法 :采用免疫组化染色法对两型鼻窦炎粘膜的 9种免疫活性细胞和 4种分泌免疫成分进行检测。结果 :鼻窦炎 型中 T淋巴细胞、T4细胞亚群、B细胞、巨噬细胞明显高于正常对照组 (P <0 .0 1) ;鼻窦炎 型中 T淋巴细胞、T8细胞亚群、B细胞、肥大细胞、嗜酸性细胞明显高于正常对照组 (P<0 .0 1) ;两型中的 T4/ T8细胞比值有明显差异 (P<0 .0 1)。结论 :两型鼻窦炎局部粘膜某些免疫活性细胞的浸润存在一定差异 ,提示其发病机理及治疗方法的选择应有区别。
Objective: To investigate the role of immunocompetent cells and secretory immune components in the defense of inflammatory processes in the local mucosa of chronic sinusitis. Methods: Nine kinds of immunocompetent cells and four kinds of secretory immune components of two types of sinusitis mucosa were detected by immunohistochemistry. Results: The numbers of T lymphocyte, T4 cell subsets, B cells and macrophages in sinusitis group were significantly higher than those in normal control group (P <0.01). The numbers of T lymphocyte, T8 cell subsets, B The numbers of cells, mast cells and eosinophils in the two groups were significantly higher than those in the normal control group (P <0.01). The ratio of T4 / T8 cells in two types was significantly different (P <0.01). Conclusion: There are some differences in the infiltration of some immunocompetent cells in the local mucosa of two types of sinusitis, suggesting that the pathogenesis and treatment options should be different.