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纤维支气管镜和支气管肺泡灌洗(BAL)已成为各种肺部疾病的一种研究手段,近年亦用该法回收哮喘病人气道细胞和其他成分,以研究其在气道高反应性和炎症中的可能作用。BAL用于哮喘的经验正常肺泡巨噬细胞(AM)可分泌血小板激活因子和各种花生四烯酸代谢产物,包括前列腺素及白三烯。同样,哮喘病人的AM受到刺激亦产生一些介质。曾对100例左右的哮喘患者用100～150ml盐水进行了BAL。最近,又有几组研究者对病情稳定的、年轻的,无症状的哮喘病人用100～300ml盐水进行了BAL。灌洗对病人无明显副作用,但在操作前或操作中必须使用预防性的支气管扩张药物或皮质类固醇。用药后是
Fiberoptic bronchoscopy and bronchoalveolar lavage (BAL) have become a means of research for a variety of lung diseases. In recent years, this method has also been used to recover airway cells and other components of asthmatic patients to study their role in airway hyperresponsiveness and inflammation In the possible role. BAL’s Experience with Asthma Normal alveolar macrophages (AMs) secrete platelet activating factor and a variety of arachidonic acid metabolites, including prostaglandins and leukotrienes. Similarly, asthma patients are stimulated AM also produce some media. About 100 cases of asthma patients with 100 ~ 150ml saline BAL. Recently, several groups of researchers conducted BAL with 100-300 ml of saline on stable, young, and asymptomatic asthmatic patients. Irrigation has no significant side effects on the patient, but prophylactic bronchodilators or corticosteroids must be used before or during the procedure. After treatment is