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整合素α4β7为黏膜归巢受体,这种黏膜归巢特性在胃肠道非霍奇金淋巴瘤(NHL)的发病中占重要地位。研究发现α4β7在胃肠道的恶性淋巴瘤性息肉病、结外边缘区B细胞淋巴瘤或MALT型淋巴瘤、小肠T细胞NHL和小肠滤泡性NHL的病理组织中表达,而非黏膜原发部位的NHL一般不表达,如出现阳性,则有可能预示非胃肠道NHL患者已有胃肠道浸润或骨髓浸润。
Integrin α4β7 is a mucosal homing receptor. This mucosal homing characteristic plays an important role in the pathogenesis of gastrointestinal non-Hodgkin’s lymphoma (NHL). It has been found that α4β7 is expressed in the pathological tissues of gastrointestinal malignant lymphoma polyposis, extranodal marginal zone B-cell lymphoma or MALT-type lymphomas, intestinal T-cell NHL and small intestinal follicular NHL, rather than mucosal primary Parts of the NHL are generally not expressed, if positive, it may indicate non-gastrointestinal NHL patients have gastrointestinal infiltration or bone marrow infiltration.