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本文的研究目的是测定单氟三氯甲烷(FC 11)、二氟二氯甲烷(FC 12)以及此二者的混合物(FC 11/FC12)在动物体内的分布及转归。[实验方法]实验用2.5%和5.0%FC 11、20%和50%FC 12以及25%和50%FC 11/FC 12(10/90)。实验动物选用狗和家兔。将动物用戊巴比妥麻醉(40mg/kg,肌注)。通过气管插管使动物吸入碳氟化合物10分钟。分析了呼气、颈动脉血、总胆管胆汁、脑脊液(只测定狗)以及尿中碳氟化合物的含量。碳氟化合物的含量用电子捕获气体色层分析方法测定。[实验结果]碳氟化合物在家兔体内的分布:血中FC12浓度,吸入开始后很快增高,约2分钟达到平衡,并一直维持到吸入结束。吸入停止时,FC 12
The purpose of this study was to determine the distribution and turnover of FC11, difluorodichloromethane (FC12) and their mixtures (FC11 / FC12) in animals. [Experimental Method] Experiments were performed with 2.5% and 5.0% FC 11, 20% and 50% FC 12 and 25% and 50% FC11 / FC12 (10/90). Experimental animals use dogs and rabbits. Animals were anesthetized with pentobarbital (40 mg / kg, intramuscularly). The animals were drawn into the fluorocarbon for 10 minutes by intubation. Exhalation, carotid blood, total bile duct, cerebrospinal fluid (dogs only) and urinary fluorocarbon levels were analyzed. The fluorocarbon content was determined by electron capture gas chromatographic analysis. [Experimental Results] Distribution of Fluorocarbons in Rabbits: Concentrations of FC12 in blood rapidly increased after inhalation started, reached equilibrium in about 2 minutes, and maintained until inhalation. When inhalation is stopped, FC 12