At the mid-late stage of diabetic nephropathy massive proteinuria, hypoproteinemia and anasarca would develop which is nephrotic syndrome. Diuretics are often insensitive and treatment is very difficult. From January 1995 to December 1998, the authors adopted intravenous dripping infusion of Astragalus injection (AI) for patients with nephrotic syndrome due to diabetic nephropathy (DN). The control group was treated by Salvia injection (SI). The result was that the group treated by AI showed obvious diuretic and detumescent effect.