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目的探讨胰岛素样生长因子结合蛋白-1(IGFBP-1)检测在胎膜早破中的应用效果。方法 91例胎膜早破孕妇设为A组,同期80例无胎膜早破孕妇设为B组。对两组孕妇阴道分泌物进行胰岛素样生长因子结合蛋白-1检测、p H试纸检测,对比分析两种检查方法的阴性预测值、阳性预测值、灵敏度、特异性。结果 A组胰岛素样生长因子结合蛋白-1检测阳性率高于p H试纸检测,B组胰岛素样生长因子结合蛋白-1检测阳性率低于p H试纸检测,差异具有统计学意义(P<0.05)。胰岛素样生长因子结合蛋白-1检测阴性预测值为96.30%,阳性预测值为97.78%,灵敏度为96.70%,特异性为97.50%,明显高于p H试纸的71.74%、82.28%、71.42%、82.50%,差异均有统计学意义(P<0.05)。结论通过检测阴道分泌物中的IGFBP-1,可以快速、准确地诊断胎膜早破的发生,且具有敏感度高、特异性好及操作简单等优点,值得临床推广应用。
Objective To investigate the effect of insulin-like growth factor binding protein-1 (IGFBP-1) detection in premature rupture of membranes. Methods Ninety-nine pregnant women with premature rupture of membranes were enrolled in group A, and 80 pregnant women without premature rupture of membranes were selected as group B during the same period. The vaginal secretions of two groups of pregnant women were tested for insulin-like growth factor binding protein-1 and p H test strips. The negative predictive value, positive predictive value, sensitivity and specificity of the two methods were compared. Results The positive rate of insulin-like growth factor binding protein-1 in group A was higher than that of p H test paper. The positive rate of insulin-like growth factor binding protein-1 in group B was lower than that of p H test paper (P <0.05 ). The negative predictive value of insulin-like growth factor binding protein-1 was 96.30%, the positive predictive value was 97.78%, the sensitivity was 96.70% and the specificity was 97.50%, which was significantly higher than 71.74%, 82.28%, 71.42% 82.50%, the difference was statistically significant (P <0.05). Conclusion Detection of vaginal secretions in the IGFBP-1, you can quickly and accurately diagnose the occurrence of premature rupture of membranes, and has the advantages of high sensitivity, specificity and simple operation, worthy of clinical application.