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目的通过对萎缩性胃炎表皮生长因子（EGF）和表皮生长因子受体（EGFR测定，探讨EGFR对萎缩性胃炎转归影响作用。方法应用EGFR单抗免疫组化ABC技术和放射免疫法对50例萎缩性胃炎和25例胃癌及19例“正常”胃粘膜组织EGFR和血清EGF水平进行检测。结果萎缩性胃炎EGFR表达的阳性率为60％，血清EGF水平平均3．54土1．47ug／L，较“正常”组（11％和1．77土0．60μg／L）明显增高，与胃癌（73％，3．72士1．84μg／L）十分接近。伴有Ⅱb型肠化者EGF水平更高。并发现EGF的高水平与EGFR高表达具有一致性。结论萎缩性胃炎体内有高水平EGF和EGFR表达。对目前使用促EGF药物治疗萎缩性胃炎提出质疑。
Objective To investigate the effect of epidermal growth factor (EGF) and epidermal growth factor receptor (EGFR) on the prognosis of atrophic gastritis in patients with atrophic gastritis.Methods EGFR monoclonal antibody immunohistochemical ABC technique and radioimmunoassay Atrophic gastritis and 25 cases of gastric cancer and 19 cases of “normal” gastric mucosa tissue EGFR and serum EGF levels were detected.Results The positive rate of EGFR expression in atrophic gastritis was 60%, serum EGF level average 3.54 soil 1.47ug / L , Which was significantly higher than that in the “normal” group (11% and 1.77 ± 0.60 μg / L), which was similar to that of gastric cancer (73%, 3.72 ± 1.84 μg / L) And found that the high level of EGF was consistent with the high expression of EGFR.Conclusion High levels of EGF and EGFR expression in atrophic gastritis are present in the body.Discussion is currently being made on the use of EGF-promoting drugs to atrophic gastritis.