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目的 :探讨食管鳞状细胞癌 p5 3蛋白及增殖细胞核抗原 (PCNA)共同表达的意义。方法 :应用免疫组化 S- P法研究 10 3例食管鳞状细胞癌 p5 3蛋白和 PCNA表达情况。结果 :p5 3蛋白阳性率为 6 0 .2 % ,PCNA高表达率为5 5 .3% ;p5 3蛋白阳性、PCNA高表达均与淋巴结转移有关 (P=0 .0 2 87,P=0 .0 0 0 7) ;当两者共同表达时 ,淋巴结转移率比其单表达者明显增高 (P<0 .0 1)。结论 :p5 3和 PCNA可能有协同作用。对食管鳞状细胞癌患者同时检测 p5 3和 PC-NA更有利于估计预后
Objective : To explore the significance of co-expression of p53 protein and proliferating cell nuclear antigen (PCNA) in esophageal squamous cell carcinoma. Methods: The expression of p53 protein and PCNA in 103 cases of esophageal squamous cell carcinoma were studied by immunohistochemical S-P method. Results: The positive rate of p53 protein was 60.2%, and the high expression rate of PCNA was 55.3%. The positive expression of p53 protein and high expression of PCNA were related to lymph node metastasis (P=0.0287, P=0). .0 0 0 7) ; When the two are co-expressed, the lymph node metastasis rate is significantly higher than that of the single expression (P < 0.01). Conclusion : P5 3 and PCNA may have synergistic effects. Simultaneous detection of p53 and PC-NA in esophageal squamous cell carcinoma patients is more conducive to the prognosis