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目的:通过检测窒息新生儿血清肌钙蛋白T(c Tn T)、肌酸激酶同工酶(CK-MB)水平的变化,探讨两者对患儿心肌损害的临床意义。方法:以该院2012年7月~2014年7月间收治的88例窒息新生儿为研究对象,根据出生时1 min Apgar评分分为重度窒息组和轻度窒息组,各44例,并以同期无窒息新生儿38例为对照组。采用免疫抑制法对新生儿血清CKMB进行检测,并采用电化学发光法对血清c Tn T进行检测,观测重度窒息组和轻度窒息组患者治疗前后的血清c Tn T、CK-MB变化,并进行相关比较。结果:通过检测发现,治疗前,重度窒息组、轻度窒息组患儿血清c Tn T、CK-MB水平高于对照组,重度窒息组患儿血清c Tn T、CK-MB水平高于轻度窒息组,差异有统计学意义(P<0.05);治疗后,重度窒息组、轻度窒息组患儿血清c Tn T、CK-MB水平低于治疗前,差异有统计学意义(P<0.05);治疗后,重度窒息组、轻度窒息组患儿血清c Tn T、CK-MB水平与对照组对比,差异无统计学意义(P>0.05)。结论:窒息新生儿血清CK-MB、c Tn T能够用来作心肌损害的监测指标,其可反映患儿心肌损害程度和治疗效果,具有较高的临床价值。
OBJECTIVE: To investigate the clinical significance of serum cTnT and CK-MB levels in neonates with asphyxia to explore their clinical significance. Methods: A total of 88 asphyxial newborns admitted to our hospital from July 2012 to July 2014 were divided into severe asphyxia group and mild asphyxia group according to 1-minute Apgar score at birth, 38 cases of asphyxiated newborns in the same period as the control group. Serum CKMB was detected by immunosuppression and serum cTn T was detected by electrochemiluminescence. Changes of serum cTnT and CK-MB before and after treatment were observed in patients with severe asphyxia and mild asphyxia For comparison. Results: The levels of cTn T and CK-MB in children with severe asphyxia and mild asphyxia were significantly higher than those in control group (P0.05). After treatment, the levels of cTn T and CK-MB in children with severe asphyxia group and mild asphyxia group were lower than those before treatment (P <0.05), and the difference was statistically significant (P0.05) 0.05). After treatment, the levels of cTn T and CK-MB in children with severe asphyxia group and mild asphyxia group were not significantly different from those in control group (P> 0.05). Conclusion: Asphyxia neonates serum CK-MB, c Tn T can be used as a marker of myocardial damage, which can reflect the degree of myocardial damage and treatment in children with high clinical value.