近年的研究认为,糖尿病是由细胞因子介导的一种低度炎症性疾病,其血清炎症标志物C-反应蛋白(C-Reactive Protein,CRP)的水平明显升高,且升高的CRP对糖尿病大血管病变(主要是冠心病、脑血管病等)有一定的预示作用,与微血管病变也可能存在某种关联,本文就这方面的研究进展作一概述。1CRP的来源、分子结构及生物学特性CRP主要是在白细胞介素6(IL-6)的调节下由 Recent studies suggest that diabetes is a cytokine-mediated inflammatory disease with markedly elevated level of serum inflammatory marker C-Reactive Protein (CRP), and elevated CRP Diabetic macroangiopathy (mainly coronary heart disease, cerebrovascular disease, etc.) have a certain predictive role, and microvascular disease may also have some relevance, this article gives an overview of the research progress in this area. 1 CRP source, molecular structure and biological characteristics of CRP is mainly in the regulation of interleukin 6 (IL-6) by