酯化反应是药物合成中的重要反应之一。一种母体药物常需制备多种酯,以获得药理作用符合需要的新药物。甾体叔醇主要有以下三种结构类型,一般位阻较大,有时易消除,因此酯化存在一定困难,对这类叔醇的酯化已有不少研究,大致归纳为下列几种方法: Esterification is one of the important reactions in drug synthesis. A parent drug often requires the preparation of a variety of esters to obtain the desired pharmacological effect of new drugs. Steroid tertiary alcohol mainly has the following three types of structure, the general steric hindrance, sometimes easy to eliminate, so there are some difficulties esterification, esterification of these tertiary alcohols have been studied, generally summarized as the following methods :