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许多作者都发现慢性肝脾型血吸虫病人肾脏损害的发病率很高。肾脏损害的特点是上皮层增厚和上皮细胞中度增生而肾小球血管壁常常不见炎症的病变。电子显微镜和免疫荧光的研究发现免疫球蛋白及补体主要沉着在上皮层同一部位,并有电子致密物质沉着。虽然这些发现都很有力的提示肾脏损害是由于免疫的原因,但在受害的肾小球从来没有找到血吸虫抗原,因此这种特殊的肾脏损害的发病机理仍不明了。相似的肾脏损害亦可发生在感染日本血吸虫的黑猩猩和感染曼氏血吸虫的卷尾猴。组织学及电子显微镜所见和人体所见的极相似,提供了研究血吸虫病人肾小球病变发病机理的动物模型。
Many authors have found that the incidence of kidney damage in patients with chronic hepatosplenic schistosomiasis is high. Kidney damage is characterized by epithelial thickening and epithelial cell hyperplasia and glomerular wall often not seen inflammatory lesions. Electron microscopy and immunofluorescence studies found that immunoglobulins and complement mainly in the same part of the epithelium, and the deposition of electron dense material. Although these findings strongly suggest that kidney damage is due to immunological causes, the schistosome antigen has never been found in the affected glomerulus, and the pathogenesis of this particular kidney damage remains unknown. Similar kidney damage can also occur in chimpanzees infected with Schistosoma japonicum and in capuchin infected with Schistosoma mansoni. Histology and electron microscopy seen and the human body to see very similar to provide an animal model of schistosomiasis patients with the pathogenesis of glomerular lesions.