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目的 :了解氯沙坦及依那普利对急性心肌梗塞 (AMI)患者左心室重塑的治疗效应。 方法 :急性心肌梗塞患者 6 3例 ,按治疗不同分为 3组 :氯沙坦组 (n=19)、依那普利组 (n=2 3)和对照组 (n=2 1) ,采用超声心动图测量入院后第 1、5、14天以及 3、6个月左心室舒张末容积指数 (L VEDVI)、左心室收缩末容积指数(L VESVI)及左心室射血分数 (L VEF)的变化 ,并进行临床观察。 结果 :对照组与入院基础值比 ,在 14天及 3个月时 L VEDVI及 L VESVI增加具有统计学显著性 (P<0 .0 5 )。氯沙坦组及依那普利组 ,与对照组比较 14天及 3个月时 L VEDVI降低具统计学显著性 (P<0 .0 5 ) ;L VESVI降低 ,14天时具统计学显著性 (P<0 .0 5 )。依那普利组咳嗽发生率 2 5 % ,而氯沙坦组无一例咳嗽发生。 结论 :氯沙坦及依那普利对 AMI患者具有相似的抗左心室重塑效应 ,氯沙坦耐受性更好
Objective: To investigate the therapeutic effect of losartan and enalapril on left ventricular remodeling in patients with acute myocardial infarction (AMI). Methods: Sixty-three patients with acute myocardial infarction were divided into three groups according to the treatment: losartan group (n = 19), enalapril group (n = 23) and control group (n = 21) The left ventricular end-diastolic volume index (L VEDVI), left ventricular end-systolic volume index (L VESVI) and left ventricular ejection fraction (L VEF) were measured by echocardiography on the 1st, 5th, 14th and 3rd, The changes and clinical observation. Results: Compared with the basal value of admission, the increase of L VEDVI and L VESVI at 14 days and 3 months were statistically significant (P <0.05). Losartan group and enalapril group. Compared with the control group, L VEDVI decreased significantly at 14 days and 3 months (P <0.05), L VESVI decreased, and was statistically significant at 14 days (P <0. 05). The incidence of cough in enalapril group was 25%, while no cough in losartan group occurred. CONCLUSION: Losartan and enalapril have similar anti-LV remodeling effects in AMI patients and better tolerated losartan