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目的观察个体化干预对变态反应病儿童持续舌下含服粉尘螨滴剂特异性免疫治疗依从性的影响。方法变态反应疾病患儿300例按出生单双日期分成无干预对照组(单日出生)及干预组(双日出生)各150例。两组患者在接受脱敏治疗后均建立脱敏档案及告知脱敏常识。对照组未予任何干预,干预组给予知识认知、心理、行为等干预措施。观察两组患者治疗的依从性。结果哮喘患者停止吸入激素和喘息急性发作例次、患者自我症状的改善评价等指标,干预组优于对照组(P<0.01);平均持续脱敏时间干预组明显长于对照组(P<0.01);干预组中60.7%的患者坚持脱敏治疗2年以上,对照组中无1例患者坚持脱敏治疗至2年。结论个体化的干预能显著提高患者舌下脱敏治疗的依从性,进而提高治疗效果。
Objective To observe the effect of individualized intervention on the adherence of the specific immunotherapy to the sustained-release sublingual mite and mite in children with allergic reaction. Methods 300 cases of children with allergic diseases were divided into non-intervention control group (single birth) and intervention group (born in double birth) each 150 cases according to single and double birth date. Two groups of patients after desensitization treatment to establish desensitization files and inform desensitization common sense. The control group without any intervention, the intervention group to give cognitive, psychological, behavioral and other interventions. Compliance was observed in both groups of patients. Results The patients with asthma stopped taking inhaled corticosteroids and wheezing acute attacks, and patients’ symptoms of self-improvement were evaluated. The intervention group was better than the control group (P <0.01), and the mean sustained desensitization time was significantly longer in the intervention group than in the control group (P <0.01) ; 60.7% of patients in the intervention group adhere to desensitization therapy for more than 2 years, none of the patients in the control group adhere to desensitization therapy to 2 years. Conclusion Individualized intervention can significantly improve the compliance of patients with sublingual desensitization therapy, thereby enhancing the therapeutic effect.