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目的应用核素显像检测2型糖尿病(T2DM)患者胃肠运动障碍,并探讨其相关代谢危险因素。方法选择2012年6月至2013年12月在第三军医大学大坪医院野战外科研究所高血压内分泌科住院的T2DM患者15例(糖尿病组),健康志愿者18名(对照组)。收集一般资料,测定生化指标、四肢神经诱发电位。通过核素显像测定胃排空及小肠运动时间。分析组间运动时间、一般资料、生化指标、影响胃排空及小肠运动时间的独立危险因素。结果与对照组相比,糖尿病组胃排空及小肠运动时间明显延长;口服葡萄糖耐量试验2 h血糖、总胆固醇(TC)及三酰甘油(TG)是T2DM患者胃排空及小肠运动时间延长的独立危险因素。结论应用核素显像可及早发现T2DM患者胃肠运动障碍;预防T2DM患者胃肠运动障碍,不仅要积极控制血糖,还需严格控制血脂。
Objective To detect gastrointestinal dyskinesia in patients with type 2 diabetes mellitus (T2DM) by radionuclide imaging and to explore the related metabolic risk factors. Methods Fifteen T2DM patients (diabetic group) and 18 healthy volunteers (control group) were admitted to Department of Hypertension and Endocrinology, Field Surgery Research Institute, Daping Hospital, Third Military Medical University from June 2012 to December 2013. Collect general information, determine biochemical indicators, limb nerve evoked potential. Gastric emptying and intestinal transit time were determined by radionuclide imaging. Analysis of inter-group exercise time, general information, biochemical indicators, affecting gastric emptying and small intestine movement independent risk factors. Results Compared with the control group, the time of gastric emptying and small intestine movement in diabetic group were significantly prolonged. The blood glucose, total cholesterol (TC) and triglyceride (TG) in oral glucose tolerance test for 2 h were the gastric emptying and small intestine movement in T2DM patients Of independent risk factors. Conclusions The application of radionuclide imaging can detect gastrointestinal motility disorders in T2DM patients as early as possible. Prevention of gastrointestinal dyskinesia in T2DM patients not only requires active control of blood glucose but also strict control of blood lipids.