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作者为提高微型包囊得率与制剂稳定性为目的,用液中于燥法包制乙基纤维素微囊,观察了明胶浓度、盐浓度、内外相体积比及搅速等物理和机械因素对包囊工艺中的一次乳剂稳定性的影响。实验用离心浊度法测定一次乳化工艺中的平均粒径与粒度分布;用光学显微镜测定微囊的粒径;胶囊个数、平均粒径、标准偏差、粒度分布等按数理统计处理;明胶溶液及乙基纤维素二氯甲烷溶液的粘度分别用园筒型转旋式粘度计于20°时进行测定;微囊得率用萤光分光光度计,于328nm处的激发波长测定标记物丹酰明胶量,并按下式计算:
In order to improve the microencapsulation yield and the stability of the preparation, the objective of this study was to investigate the effects of physical and mechanical factors such as gelatin concentration, salt concentration, volume ratio of internal and external phases and stirring speed Effect on primary emulsion stability in the encapsulation process. The average particle size and particle size distribution in an emulsification process were determined by centrifugal turbidimetry. The particle size of microcapsules was determined by optical microscope. The number of capsules, the average particle size, the standard deviation and the particle size distribution were determined by mathematical statistics. The gelatin solution And ethyl cellulose solution of methylene chloride were measured with a rotary spindle viscometer at 20 ° when measured; microcapsules with a fluorescence spectrophotometer at a wavelength of 328nm at the excitation wavelength of the marker dansyl Gelatin volume, and according to the following formula: