内毒素在血液中循环是引起内毒素休克及其临床症象的重要因素。目前还没有一种药物能成功地治疗内毒素休克。木文旨在探讨使用新近研制的多粘菌素固定纤维(PMX-F)直接进行血液灌洗,能否有效地治疗狗内毒素和细菌性休克。将纤维截体和硫酸多粘菌素B混合或再加入一种肽缩合剂制成PMX-F。实验方法:1.PMX-F体外解毒能力的测定:在30 ml内毒素(ET)盐溶液内加入1gPMX-F使最终浓度达7.35、2、0.42和0.018 ng/ml,置37℃中90分钟。然后计算出ET残留浓度。2.PMX-F对鼠的作用:将2g PMX-F加入20mlLP5液(lipopolysac-charide)每ml水中含E·Coli 0111:B_40.5mg中, Endotoxin circulating in the blood is caused by endotoxic shock and its clinical symptoms as an important factor. There is currently no drug that successfully treats endotoxic shock. Mu Wen aims to explore the use of newly developed polymyxin fixed fiber (PMX-F) direct blood lavage can effectively treat dog endotoxin and bacterial shock. PMX-F is made by mixing fiber cross-section with polymyxin B or adding a peptide condensing agent. Experimental methods: 1. Determination of in vitro detoxification of PMX-F: 1g PMX-F was added to 30 ml of endotoxin (ET) salt solution to give final concentrations of 7.35, 2, 0.42 and 0.018 ng / ml, . Then calculate the ET residual concentration. Effect of PMX-F on mice: Add 2 g of PMX-F to 20 ml of lipopolysac-charide containing E. Coli 0111: B-40.5 mg per ml of water,