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目的 探讨外周静脉滴注 (IVD)、支气管动脉灌注 (BAI)和经支气管动脉与肺动脉双重灌注 (DAI)化疗方法治疗中晚期非小细胞肺癌的临床效果。方法 对我院 1980年以来 3种给药途径治疗中晚期非小细胞肺癌 (NSCLC) 4 43例 (其中IVD 30 1例 ,BAI 64例 ,DAI 78例 )进行回顾性分析。结果 3种方法的近期有效率分别达 5 3.4%、73.5 %、98.7% ,中位生存期达 7.3、10 .8和 12 .4个月 ,差异有显著性。结论 采用单纯BAI能使高浓度化疗药物作用于肿瘤局部 ,缩瘤率高 ,而采用DAI能弥补单纯BAI的某些不足 ,不仅提高疗效 ,也提高手术切除率
Objective To investigate the clinical effects of peripheral intravenous drip (IVD), bronchial arterial infusion (BAI), and transbronchial and pulmonary artery double perfusion (DAI) chemotherapy for the treatment of advanced non-small cell lung cancer. Methods We retrospectively analyzed 4 43 cases of advanced non-small cell lung cancer (NSCLC) in our hospital since 1980, including IVD 30 1 case, BAI 64 cases and DAI 78 cases. Results The recent efficiency of the three methods reached 5 3.4%, 73.5 % and 98.7% respectively, and the median survival time was 7.3, 10.8 and 12.4 months. The difference was significant. Conclusion The use of pure BAI can make high-concentration chemotherapeutic drugs act on local tumors with a high rate of tumor shrinkage. DAI can make up for some deficiencies of pure BAI, which not only improves the efficacy but also improves the resection rate.