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目的 :探讨叶酸对红细胞生成素 (r Hu Epo)疗效的影响。方法 :将 42例尿毒症患者中对 r Hu Epo疗效差的 9例作为实验组 ,随机抽取 5例作为治疗组加用叶酸 1 0 mg,每日 3次 ,余 4例作为对照组 ,不补充叶酸。两组均持续应用 r Hu Epo及铁剂。结果 :治疗组病人红细胞压积 (HCT)较前显著升高 (P<0 .0 1 ) ,红细胞体积 (MCV)显著下降 (P<0 .0 5) ,网织红细胞 (RC)显著升高 (P<0 .0 1 )。结论 :叶酸可改善 r Hu Epo的疗效。当用 r Hu Epo治疗肾性贫血时 ,如果疗效差 ,MCV升高 ,应据病情补充叶酸。
Objective: To investigate the effect of folic acid on the efficacy of erythropoietin (r Hu Epo). Methods: Ninety-two patients with uremia who had poor response to r Hu Epo were selected as the experimental group. Five patients were randomly selected as the treatment group plus folic acid 10 mg three times a day, with the remaining four as the control group, without supplementation Folic acid. Both groups continued to use r Hu Epo and iron. Results: The hematocrit (HCT) in treatment group was significantly higher than that before treatment (P <0.01), the volume of erythrocytes (MCV) was significantly decreased (P <0.05), and the reticulocyte (RC) (P <0. 01). Conclusion: Folic acid can improve the efficacy of r Hu Epo. When r Hu Epo treatment of renal anemia, if the curative effect is poor, MCV increased, the condition should be supplemented with folic acid.