目的:分析影响CT增强高压注射外渗的相关因素，并提出预警性的防护对策。方法:以2019年4—10月于郑州大学第一附属医院进行CT增强检查的31 595例患者作为研究对象，根据其是否发生高压注射外渗将患者分为外渗组（n n=21）和无外渗组（n n=31 574），收集其临床资料，分析CT增强高压注射外渗的相关因素。n 结果:进行CT增强检查31 595例患者中发生高压注射外渗21例，占0.07%。单因素分析显示，外渗组患者年龄、注射速率、对比剂浓度、渗透压、是否有化疗史和注射护士的工作年限与无外渗组比较，差异均有统计学意义（n P<0.05）。多因素Logistic回归分析显示，患者年龄、注射速率、对比剂浓度、渗透压、化疗史和注射护士工作年限是影响CT增强高压注射外渗的相关因素（n P<0.05）。n 结论:影响CT增强高压注射外渗的相关因素包括患者年龄、疾病类型、注射速率、对比剂浓度、渗透压、注射护士工作年限、化疗史，采取积极防护措施对减少对比剂外渗和患者痛苦具有重要意义。“,”Objective:To explore the related factors affecting the extravasation of CT enhanced high-pressure injection, and propose protective countermeasures for early warning intervention.Methods:From April to October 2019, 31 595 patients undergoing CT enhanced examination in the First Affiliated Hospital of Zhengzhou University were selected as the research subject. Patients were divided into extravasation group (n n=21) and no extravasation group (n n=31 574) according to whether they had extravasation of high-pressure injection. We collected clinical data and analyzed the related factors of extravasation of CT-enhanced high-pressure injection.n Results:Among 31 595 patients undergoing CT enhanced examination, there were 21 cases with high-pressure injection extravasation, accounting for 0.07%. Univariate analysis showed that there was a statistical difference in the age, injection rate, contrast agent concentration, osmotic pressure, history of chemotherapy and working years of injection nurses between extravasation group and no extravasation group (n P<0.05) . Multivariate Logistic regression analysis showed that patient age, injection rate, contrast agent concentration, osmotic pressure, history of chemotherapy, and working years of injection nurses were related factors that affected the extravasation of CT enhanced high-pressure injection with a statistical difference (n P<0.05) .n Conclusions:Related factors that affect CT enhanced high-pressure injection extravasation include patient age, disease type, injection rate, contrast agent concentration, osmotic pressure, working years of injection nurses, and history of chemotherapy.Taking active protective measures is of great significance to reduce the extravasation of contrast agent and the suffering of patients.