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目的:探讨血管紧张素Ⅱ-厄贝沙坦片对高血压患者合并高尿酸血症的影响和治疗作用。方法:将2010年5月期间收治的80例高血压合并高尿酸血症病人随机均分为治疗组和对照组,治疗组口服厄贝沙坦片150mg/天;对照组给予硝苯地平缓释片20mg,一日2次,疗程均为8周。结果:(1)两组降压总有效率差异无显著性(治疗组为90.8%,对照组为89.2%,P>0.05);(2)治疗后,厄贝沙坦胶囊组血清尿酸水平明显下降(P<0.01),而对照组血尿酸水平无明显变化。结论:厄贝沙坦片能同时有效降压和降低血尿酸水平。
Objective: To investigate the effect of angiotensin Ⅱ-irbesartan tablets on hypertensive patients with hyperuricemia and its therapeutic effect. Methods: 80 cases of hypertensive patients with hyperuricemia admitted in May 2010 were randomly divided into treatment group and control group. The treatment group was given oral irbesartan tablets 150mg / day. The control group was given nifedipine sustained release 20mg tablets, 2 times a day, treatment are 8 weeks. Results: (1) There was no significant difference between the two groups in the total effective rate of hypotension (90.8% in the treatment group and 89.2% in the control group, P> 0.05); (2) After treatment, the serum uric acid level of irbesartan capsule group was significantly (P <0.01), while the level of serum uric acid in the control group had no significant change. Conclusion: Irbesartan can reduce blood pressure and blood uric acid simultaneously.