目的分析安徽省2008-2014年手足口病流行病学特征,为制定手足口病干预措施提供依据。方法数据来源于中国疾病预防控制信息系统,采用描述流行病方法对安徽省2008-2014年手足口病流行病特征及病原检测资料进行统计分析。结果安徽省2008-2014年共报告手足口病病例603 975例,年平均发病率为143.09/10万,报告重症病例3 186例,占病例总数的0.52%,报告死亡病例130例,病死率为21.51/10万。发病水平呈现逐年上升趋势。发病高峰为4-6月份和11-12月份;安徽省皖北地区发病率高于皖中地区、皖南地区;病例以5岁以下儿童为主,占91.45%,发病率最高的为1~2岁组。轻症病例、重症病例、死亡病例的EV71构成比分别为48.40%、86.36%、90.57%。结论手足口病呈现明显季节性、地区性、人群高发性,针对手足口病重点人群,特别是高发季节,行政部门应采取积极有效措施。 Objective To analyze the epidemiological characteristics of hand, foot and mouth disease in Anhui Province from 2008 to 2014 and provide evidence for the development of hand foot and mouth disease interventions. Methods Data were collected from China Disease Prevention and Control Information System. Epidemiological methods were used to analyze the epidemiological characteristics and pathogen detection data of hand-foot-mouth disease in Anhui province from 2008 to 2014. Results A total of 603 975 HFMD cases were reported in Anhui province during 2008-2014, with an average annual incidence of 143.09 per 100 000 cases. A total of 3 186 severe cases were reported, accounting for 0.52% of the total cases. 130 cases were reported dead and the case fatality rate was 21.51 / 100,000. The incidence showed an upward trend year by year. The incidence peak was from April to June and from November to December. The incidence in northern Anhui Province was higher than that in Anhui Province and southern Anhui Province. The cases were mainly children under 5 years old, accounting for 91.45% and the highest incidence rate was 1-2 Age group The EV71 of mild cases, severe cases and death cases were 48.40%, 86.36% and 90.57%, respectively. Conclusion Hand, foot and mouth disease is obviously seasonal, regional and crowdable. For the key population of HFMD, especially in high season, the administrative department should take active and effective measures.