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目的:探讨交叉科学创新创业教学在口腔医学专业本科生创新能力培养中的应用效果。方法:选取2015年至2019年华中科技大学同济医学院参加大学生创新创业项目的32名口腔医学专业本科生为研究对象，将其分为试验组和对照组。试验组13名学生，采用交叉科学创新创业教学；对照组19名学生，采用传统医学创新创业教学。授课后对32名本科生的创新创业能力进行评估，采用n χ2检验、Mann-Whitney n U检验和n t检验比较两组间差异。n 结果:试验组学生的创新创业成果评分高于对照组学生[15(7，28)分比4(4，10)分]，其差异具有统计学意义(n P＝0.011)。两组学生的创新创业能力自我评价结果分别为(3.59±0.47)分和(3.70±0.76)分，其差异无统计学意义(n P＝0.636)。n 结论:交叉科学创新创业教学有助于口腔医学专业本科生取得更多创新创业成果，并提高其创业创新能力。“,”Objective:To explore the teaching effect of the interdisciplinary science based innovation and entrepreneurship education on stomatology undergraduates\' innovation competency.Methods:Undergraduates from Stomatology School, Tongji Medical College, Huazhong University of Science and Technology participated in national undergraduate training program for innovation and entrepreneurship from 2015 to 2019. Thirty-two students from the program were selected with 13 in experimental group and 19 in control group. The innovation and entrepreneurship competency were evaluated after teaching. The total scores were compared by n χ2 test, Mann-Whitney n U test and n t test.n Results:The innovation and entrepreneurship achievement score from experimental group was significantly higher than that from the control group [15(7, 28) n vs. 4(4, 10), n P=0.011]. Self-evaluation of innovation and entrepreneurship competency between the two groups showed no statistical difference [(3.59±0.47)n vs.(3.70±0.76), n P=0.636].n Conclusions:The interdisciplinary science based innovation and entrepreneurship education is helpful for stomatology undergraduates to obtain more innovative and entrepreneurial achievements and improve their entrepreneurial and innovative competency.