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目的比较DA与IA方案治疗成人初治急性髓系白血病的疗效。方法选取2013年2月—2015年3月贵州省人民医院诊断为初治急性髓系白血病的成年患者100例,随机分为研究组和对照组,各50例。研究组接受去甲氧柔红霉素+阿糖胞苷巩固治疗,对照组接受柔红霉素+阿糖胞苷巩固治疗。比较两组中性粒细胞恢复时间、治疗期间白细胞最低值、临床疗效、治疗后1年无病生存率。结果研究组中性粒细胞恢复时间短于对照组,治疗期间白细胞最低值高于对照组,总有效率高于对照组,1年无病生存率高于对照组,差异有统计学意义(P<0.05)。结论IA方案治疗急性髓系白血病的疗效优于DA方案,患者诱导期间骨髓抑制轻,生存期长。
Objective To compare the efficacy of DA and IA regimens in the treatment of adult patients with acute myeloid leukemia. Methods 100 adult patients diagnosed as newly diagnosed acute myeloid leukemia in Guizhou Provincial People’s Hospital from February 2013 to March 2015 were randomly divided into study group and control group, with 50 cases in each group. The study group received the combination of daunorubicin plus cytarabine and the control group received daunorubicin plus cytarabine. The time of neutrophil recovery, the lowest leukocyte count, the clinical efficacy and the 1-year disease-free survival rate after treatment were compared between the two groups. Results The recovery time of neutrophils in the study group was shorter than that in the control group. The lowest leukocyte count in the treatment group was higher than that in the control group, and the total effective rate was higher than that in the control group. The 1-year disease-free survival rate was significantly higher than that in the control group <0.05). Conclusions The efficacy of IA regimen in the treatment of acute myeloid leukemia is superior to that of DA regimen. The patients with myelosuppression are light and have long survival period.