目的与方法:应用聚合酶链反应(PCR)技术对56例肺癌石蜡包埋标本进行C-myc基因的研究.结果:C-myc基因扩增与组织学类型、临床病理分期及淋巴结转移有密切关系(P<0.05),C-myc基因扩增者,分化程度较低,临床病理分期较晚,淋巴结转移多.同时还发现C-myc基因扩增与预后有明显关系(P<0.05),C-myc基因扩增者预后较差.结论:提示C-myc基因可以作为判断肺癌预后的检测指标之一. Objective and Methods: To investigate the C-myc gene in 56 paraffin-embedded lung cancer specimens by polymerase chain reaction (PCR). Results: C-myc gene amplification is closely related to histological type, clinical pathological stage and lymph node metastasis. The relationship (P<0.05), C-myc gene amplification, lower differentiation, late clinical pathological stage, lymph node metastasis, also found that C-myc gene amplification was significantly related to prognosis (P<0.05). The prognosis of C-myc gene amplification is poor. Conclusion: C-myc gene can be used as one of the indicators to determine the prognosis of lung cancer.