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目的 :探讨黄连素、山莨菪硷 (山黄合剂 )合用对急性高原性肠炎 (肠炎 )的防治 ;方法 :对象为急进高原 2 0 0名部队健康青年。 15 0名进行肠炎的流行病学调查 ,对诊断为肠炎的 10 3例患者随机分A组 ,73例 ,服黄连素 3 5 0mg,予山莨菪硷 2 0mg(预防分别为 2 0 0mg、10mg) 3 /d ;B组 ,3 0例 ,服诺氟沙星胶囊 2粒 ,4/d。 5 0名在进驻高原时开始服黄连合剂 ,3 /d ,连服 5天 ,观察服药后的防治效果 ;结果 :服药 1次～ 5次治愈 ,A组 67例 ,B组 14例 ,治愈率分别是 93 %和 49%。B组治疗无效 16例 ,改用A组方法治疗 1次～ 4次 ,14例治愈 ,治愈率 88%。 5 0名服药预防 5天 ,46例未出现上述症状 ,有效保护率 92 %。两组治疗效果和预防与未经预防患病率比较有非常显著差别 (P <0 .0 1和P <0 .0 0 1) ;结论 :A组治疗效果显著优于B组 ,并有较好的预防效果。
Objective: To investigate the prevention and treatment of acute high-altitude enteritis (enteritis) in combination with berberine and anisodamine (Shanhuang Mixture); Methods: The subjects were 200 healthy young volunteers in the acute plateau. 15 0 epidemiological survey of enteritis, 103 cases diagnosed as enteritis were randomly divided into group A, 73 cases, serving berberine 350mg, to Anisodamine 20mg (prevention were 200mg, 10mg ) 3 / d; group B, 30 patients served norfloxacin capsules 2, 4 / d. 50 were in the plateau started serving Huang Huang combination agent, 3 / d, and even served 5 days, observed after taking the control effect; results: taking 1 to 5 times the cure, A group of 67 cases, B group of 14 cases, the cure rate 93% and 49% respectively. Group B treatment ineffective in 16 cases, switch to group A treatment 1 to 4 times, 14 cases were cured, the cure rate was 88%. 50 patients for 5 days to prevent medication, 46 patients did not appear the above symptoms, the effective protection rate of 92%. There was a significant difference between the two groups in the treatment effect and the prevention and the non-prevention of the disease (P0.01 and P0.01). Conclusion: The treatment effect in group A was significantly better than that in group B Good preventive effect.