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用酶联免疫检测技术对慢性肝病患者血清Ⅰ型胶原及TNFα进行了检测。结果表明,随着慢性肝病进行性发展,其血清含量逐渐增加。相关性分析表明二指标之间及与γ-球蛋白呈正相关。Ⅰ型胶原与TNFα联合诊断可提高诊断符合率。以上结果提示,Ⅰ型胶原和TNFα是反映肝纤维化程度的良好指标。TNFα对Ⅰ型胶原的合成与分泌具有调节作用。胶原成分与细胞因子联合诊断肝硬化,可互相弥补其局限性,显示了联合诊断的优越性。
Enzyme-linked immunosorbent assay was used to detect serum type I collagen and TNFα in patients with chronic liver disease. The results show that with the progressive development of chronic liver disease, the serum levels gradually increased. Correlation analysis showed that there was a positive correlation between the two indexes and γ-globulin. Type Ⅰ collagen and TNFα combined diagnosis can improve diagnostic accuracy. The above results suggest that type I collagen and TNFα reflect the degree of liver fibrosis as a good indicator. TNFα has a regulatory effect on the synthesis and secretion of type I collagen. Collagen composition and cytokines in the diagnosis of cirrhosis, each other to make up for its limitations, shows the superiority of the joint diagnosis.