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目的：为探讨新生儿肺炎血清SIL-2R水平变化特点及其临床意义。方法：用双抗夹心ELISA法检测36树新生儿肺炎、50例新生儿脐血、52例健康成人的血清SIL－2R水平。结果：脐血血清SIL-2水平（216．91±61.79u／ml）明显高于成人（164．93±57.81u／ml），P＜0．001；患儿血清SIL－2R水平治疗前（533.19±154.30u／ml）明显高于脐血对照（P＜0．001），治愈后（401．68±92．35u／ml）明显低于治疗前（P＜0.001）：经多元相关分析，血清SIL－2R水平与病情轻重密切相关（r=0．85，p＜0．01），而与生后日龄、外周血WBC数、淋巴细胞数无相关（P＞0．05）结论：血清SIL－2R水平可作为新生儿肺炎病情监视及疗效判断的参考指标。
Objective: To investigate the changes of serum SIL-2R level in neonatal pneumonia and its clinical significance. Methods: The serum levels of SIL-2R in 36 neonates with pneumonia, 50 neonates with cord blood and 52 healthy adults were detected by double-antibody sandwich ELISA. Results: The serum levels of SIL-2 in cord blood were 216.91 ± 61.79u / ml significantly higher than those in adults (164.93 ± 57.81u / ml) (P <0.001) 533.19 ± 154.30u / ml) were significantly higher than that of umbilical cord blood (P <0.001), and were significantly lower after treatment (401.68 ± 92.35u / ml) than those before treatment (P <0.001) The level of serum SIL-2R was closely related to the severity of illness (r = 0.85, p <0.01), but not to the number of WBC and lymphocyte in peripheral blood at postnatal day (P> 0.05) Serum SIL-2R levels can be used as neonatal pneumonia disease monitoring and curative effect judgment reference index.