高胰岛素-正葡萄糖钳夹技术通过同时外源性输注胰岛素和葡萄糖,将血糖维持在设定的稳态,最初用于评价机体的胰岛素敏感状况,近年来也用于评估胰岛素制剂的药理学特点,被公认为是评价胰岛素作用的“金标准”。以往常用的基础胰岛素制剂-中性鱼精蛋白锌胰岛素(NPH)的作用常有明显的峰值,不仅增加了夜间低血糖事件发生的危险,而且作用持续时间一般只有12～14h,每日一次注射常不能满足治疗的需要。正糖钳夹研究证实,新型长效胰岛素类似物作用持续时间接近24h,且作用曲线平缓,峰值更低,被认为 High-Insulin-Positive Glucose Clamp The technique was originally used to assess the body’s insulin sensitivity by simultaneously exogenously administering insulin and glucose to maintain blood glucose at a steady state set and has also been used in recent years to evaluate the pharmacology of insulin preparations Characteristics, is recognized as the evaluation of the role of insulin “gold standard ”. The commonly used basic insulin preparation - neutral protamine zinc insulin (NPH) often have significant peak role, not only increased the risk of nocturnal hypoglycemia, and the duration of the effect is usually only 12 ~ 14h, once daily injection Often can not meet the needs of treatment. Positive glucose clamp study confirmed that the role of new long-acting insulin analogues close to 24h duration, and the role of the curve is flat, the peak is lower, is considered