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目的为了探讨可溶性细胞间粘附分子-1(SICAM-1)、肿瘤坏死因子-α(TNF-α)和一氧化氮(NO)此三种物质在急性白血病中的作用及相关性,我们对80例急性白血病(AL)患者进行了检测。方法清晨空腹抽取静脉血3ml,分离血清,-40℃保存待测,相关分析采用单因素直线相关分析。结果初发与复发/难治急性白血病(AL)患者血清SICAM-1、TNF-α、NO水平显著高于正常对照及骨髓缓解组(P<0.01);SICAM、TNF-α、NO水平无显著差异(P<0.05),骨髓缓解组与正常对照组相比血清SICAM-1、TNF-α、NO水平无显著差异(P<0.05),急性白血病(AL)患者血清SICAM-1、TNF-α、NO呈显著正相关。结论血清SICAM-1、TNF-α、NO可以作为急性白血病(AL)患者辅助诊断及疗效的观察指标。
Objective To investigate the role of SICAM-1, tumor necrosis factor-α (TNF-α) and nitric oxide (NO) in acute leukemia and their correlation, Eighty patients with acute leukemia (AL) were tested. Methods Fasting blood samples were drawn in 3ml at early morning, serum was separated and stored at -40 ℃. Correlation analysis was performed by single factor linear correlation analysis. Results Serum levels of SICAM-1, TNF-α and NO in patients with primary and recurrent / refractory acute leukemia (AL) were significantly higher than those in normal control group and bone marrow remission group (P <0.01) (P <0.05). There was no significant difference in serum SICAM-1, TNF-α and NO between the bone marrow remission group and the normal control group (P <0.05). The levels of SICAM-1 and TNF- α in the patients with acute leukemia , NO was significantly positive correlation. Conclusions Serum SICAM-1, TNF-α and NO can be used as auxiliary indicators in the diagnosis and treatment of acute leukemia (AL).