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用中药防治肝癌栓塞化疗术 (Transcatheterarterialchemoembolization,TACE或TAE)后的毒副反应。方法 :中药组44例患者在TACE后连续服用清热柔肝的中药 ;对照组46例患者在TACE后 ,当出现中度发热、高热时 ,分别予以消炎痛、复方氨基比林或地塞米松 ,观察两组TACE后毒副反应的情况。结果 :中药组高热、中热、低热的发生率分别为25 % (11/44)、36 36 % (16/44)、31 82 % (14/44) ,对照组高热、中热、低热的发生率分别为50 % (23/46)、39 13 % (18/46)、8 70 % (4/46) ,两组的发热程度比较 ,P<0 01 ,有非常显著性差异 ;中药组的重度、中度、轻度疼痛的发生率分别为0 %、4 55 % (2/44)、43 18 % (19/44) ,对照组重度、中度、轻度疼痛的发生率分别为2 17 % (1/46)、23 91 % (11/46)、39 13 % (18/46) ,两组的疼痛程度比较 ,P<0 05 ,有显著性差异 ;黄疸发生率 ,中药组为13 44 % (6/44) ,对照组为4 34 % (2/46) ,两组比较 ,P>0 05 ,无显著性差异 ;呕吐发生率 ,中药组为22 73 % (10/44) ,对照组为19 56 % (9/46) ,两组比较 ,P>0 05 ,无显著性差异。中药组未见因服用中药而引起的不良反应。结论 :清热柔肝法对TACE后的发热和疼痛 ,具有良好的防治作用。
The side effects of traditional Chinese medicine in prevention and treatment of hepatocellular carcinoma embolization chemotherapy (TACE or TAE). METHODS: Forty-four patients in the Chinese Herbal Medicine Group continued to take traditional Chinese medicine for heat and softening of the liver after TACE; 46 patients in the control group received indomethacin, compound aminopyrine or dexamethasone when moderate fever and high fever occurred after TACE, respectively. Observe the situation of toxic and side reactions after two groups of TACE. Results: The incidence of high fever, moderate heat and low fever in the Chinese medicine group was 25% (11/44), 3636% (16/44), and 31 82% (14/44) respectively. The control group had high fever, moderate heat and low fever. The incidences were 50% (23/46), 39 13% (18/46), and 87% (4/46) respectively. There was a significant difference between the two groups in the degree of fever (P<0.01). The incidence of severe, moderate, and mild pain was 0%, 455 (2/44), and 43 18% (19/44), respectively. The incidence of severe, moderate, and mild pain in the control group was 2 17% (1/46), 23 91% (11/46), 39 13% (18/46), Pain in the two groups, P<0 05 , with significant difference; incidence of jaundice, Chinese medicine group The rate was 13 44% (6/44) in the control group and 434 (2/46) in the control group. There was no significant difference between the two groups, P>0.05, and the incidence of vomiting was 22 73% in the Chinese medicine group (10/44). The control group was 19 56% (9/46). There was no significant difference between the two groups, P>0.05. The Chinese medicine group did not see adverse reactions caused by taking Chinese medicine. Conclusion: The method of heat-relaxing and softening liver has good preventive and therapeutic effects on fever and pain after TACE.