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本文对急性间质性肾炎(AIN)病理形态学的改变与临床、预后关系进行了探讨。30例 AIN 肾组织学诊断依据:肾皮质有炎性反应,间质区域有淋巴细胞和浆细胞浸润,有时亦可有(?)酸性粒细胞浸润,间质可有水肿,但无纤维化。肾小球通常无明显改变,但亦有1/3患者可有轻微的系膜细胞增殖,与轻微型毛细血管内膜增殖性肾小球肾炎的病理变化相类似。荧光显微镜和电子显微镜检查发现20例患者出现典型的抗肾小管基底膜(抗 TBM)肾炎的表现。对其中4例用 PAP(peroxidase anti-peroxidase 过氧化酶-抗过氧化酶)的方法检查,仅1例发现沿着肾小管基底膜有颗粒状 IgG 沉积。本
In this paper, the pathological changes of acute interstitial nephritis (AIN) and clinical, prognosis were discussed. 30 cases of AIN renal histological diagnosis based on: renal cortex inflammatory reaction, interstitial lymphocytes and plasma cells infiltration, and sometimes (?) Acid granulocyte infiltration, interstitial edema, but no fibrosis. Glomerular usually no significant change, but 1 in 3 patients may have mild mesangial cell proliferation, and micro capillary endometrial proliferative glomerulonephritis similar to the pathological changes. Fluorescence microscopy and electron microscopy revealed the presence of a typical anti-tubulointerstitial (anti-TBM) nephritis in 20 patients. In 4 of them, PAP (peroxidase anti-peroxidase-peroxidase) was used for examination. In only 1 case, granular IgG deposition was found along the tubular basement membrane. this