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目的 探讨三金片对老年顽固性尿路感染所致膀胱痉挛患者的临床疗效及安全性.方法 选取60 例老年膀胱痉挛患者, 随机数字法分成两组, 每组30 例.所有患者均给予左氧氟沙星抗感染治疗, 对照组在此基础上给予盐酸坦索罗辛治疗, 研究组在对照组治疗基础上再给予三金片治疗, 均连续治疗4 周.检测治疗前后外周血T 淋巴细胞亚群、尿分泌型免疫球蛋白 A (SIgA)水平以及排尿有关指标, 观察其临床疗效及安全性.结果 与治疗前比较, 两组外周血CD4 +、 CD4 +/CD8 +升高(P 0.05), 尿 SIgA 水平降低(P <0.05), 最大尿流速率(Qmax)以及平均尿流速率(Qave)升高(P <0.05), 生活质量评分(QOL)以及膀胱残余尿量(PVR)降低(P <0.05);与对照组比较, 研究组外周血CD4 +、 CD4 +/CD8 +较高(P0.05), Qmax以及Qave较高(P<0.05), QOL 以及 PVR 较低(P <0.05), 有效治疗率较高(P 0.05).结论 三金片治疗老年膀胱痉挛效果确切, 明显改善机体免疫功能以及排尿困难症状.“,”Objective To investigate the efficacy and safety of Sanjin Tablets in the treatment of bladder spasm induced by intractable urinary tract infection in elderly patients.Methods 60 elderly patients with bladder spasm were divided into the control group and the study group according to random number table.All patients were treated with levofloxacin.The control group was addi-tionally given tamsulosin hydrochloride.The study group was additionally given tamsulosin hydrochloride plus Sanjin tablets.The treatment lasted 4 weeks.Peripheral blood T lymphocyte subsets, urinary sIgA levels were measured.The urine dynamic examination was performed.The clinical efficacy and safety were observed.Results Compared with before treatment, the levels of CD4 +and CD4 +/CD8 +were increased in two groups after treatment (P0.05).Urinary sIgA level was decreased (P<0.05).Qmax and Qave were increased (P<0.05).QOL and PVR were decreased (P<0.05).Com-pared with the control group, the levels of CD4 +and CD4 +/CD8 +in the study group were higher (P0.05).Qmax and Qave were higher (P<0.05).QOL and PVR were lower (P<0.05).The response rate was higher in the study group than that in the control group (P0.05).Conclusion Sanjin tablet is effective in the treatment of senile bladder spasm.It can improve the immune function and difficulty of urinating.