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目的评价法罗培南钠片(青霉烯类抗生素)治疗临床常见致病菌引起的呼吸、泌尿系统细菌感染性疾病的疗效和安全性。方法用多中心随机双盲单模拟阳性药平行对照试验方法,共入选有效病例226例,试验组(法罗培南钠)入选114例,对照组(头孢泊肟酯)入选112例,法罗培南钠片每日600mg,头孢泊肟酯片每日200mg,疗程均为7~14天。结果试验组与对照组临床痊愈率分别为83.33%和80.36%,总有效率分别为95.61%和95.54%;细菌清除率均为98.94%。药物不良反应发生率分别为6.84%和6.14%。结论法罗培南钠片治疗临床常见急性细菌性感染安全、有效。
Objective To evaluate the efficacy and safety of faropenem sodium tablets (penem antibiotics) in the treatment of respiratory and urinary tract bacterial infections caused by common pathogenic bacteria. Methods A multicenter, randomized, double-blind, single-dose, positive-phase, parallel, controlled trial was used. A total of 226 valid cases were enrolled. 114 were treated with faropenem, 112 were treated with cefpodoxime, Daily 600mg, cefpodoxime proxetil 200mg daily, treatment are 7 to 14 days. Results The clinical cure rates of the experimental group and the control group were 83.33% and 80.36%, respectively. The total effective rates were 95.61% and 95.54% respectively. The bacterial clearance rate was 98.94%. Adverse drug reactions were 6.84% and 6.14% respectively. Conclusion Faropenem sodium tablets are safe and effective in the treatment of common acute bacterial infections.