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目的 探讨小儿充血性心力衰竭 (CHF)时血浆一氧化氮 (NO)的变化及意义。方法 测定先天性心脏病合并CHF组 17例与健康小儿作对照组 15例、支气管肺炎 (支肺炎 )合并CHF组 16例与支气管肺炎组 15例及支肺炎合并CHF纠正前后的血浆NO水平。结果 先天性心脏病合并CHF组的血浆水平高于对照组且差异有非常显著意义 (P <0 0 0 1) ,支肺炎合并CHF组 (CHF纠正前 )的血浆NO水平高于支肺炎组且差异有非常显著意义 (P <0 0 0 1)。结论 CHF患儿的血浆NO水平升高是CHF患儿的病理生理特征之一 ,NO参与CHF的病理生理 ,可作为判断CHF的一个辅助指标。
Objective To investigate the changes and significance of plasma nitric oxide (NO) in children with congestive heart failure (CHF). Methods Twenty-seven patients with congenital heart disease complicated with CHF and 15 healthy children were enrolled in this study. Plasma NO levels in bronchial pneumonia (pneumonia) with CHF group (16 cases) and bronchial pneumonia group (15 cases) and pneumonia with pneumonia before and after correction were measured. Results Plasma levels of congenital heart disease complicated with CHF group were significantly higher than those of control group (P <0.01). Plasma levels of NO in bronchiectasis pneumonia combined with CHF group (before CHF correction) were higher than those in pneumonia group The difference was significant (P <0.01). Conclusions The elevated plasma levels of NO in children with CHF are one of the pathophysiological features in children with CHF. NO participates in the pathophysiology of CHF and may serve as an adjunct to CHF.