论文部分内容阅读
从我国湖北潜江县土壤分离的一株链霉菌产生的C1027是大分子肽类抗生素,其发色基团是新的烯二炔化合物。研究表明,抗生素C1027对肿瘤细胞有强烈杀伤作用。C1027在精原细胞法检测中显示高度活性,比阿霉素、丝裂霉素C等强500倍。由发色基团和蛋白质两部分构成的C1027分子可以拆分与重建;而重建的C1027分子同样具有很强的活性。在可耐受剂量,C1027对移植性小鼠结肠癌26以及对移植于裸鼠的人体肝癌和盲肠癌均有显著的疗效。
C1027 from a Streptomyces isolated from soil in Qianjiang County, Hubei Province, China, is a macromolecular peptide antibiotic whose chromophore is a new enediyne compound. Studies have shown that the antibiotic C1027 has a strong killing effect on tumor cells. C1027 showed high activity in the spermatogonia test, 500-fold more potent than doxorubicin, mitomycin C and the like. The C1027 molecule, which is composed of chromophore and protein, can be resolved and reconstructed. The reconstituted C1027 molecule also has strong activity. At tolerable doses, C1027 has a significant therapeutic effect on transplanted mouse colon cancer26 and on human liver cancer and cecal cancer transplanted in nude mice.