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目的 :探讨非清除性异基因干细胞移植在难治性急性白血病治疗中的作用。方法 :3例难治性急性白血病 ,采用环胞霉素 A、环磷酰胺、阿糖胞苷或抗淋巴细胞球蛋白等作非清除性预处理的异基因外周造血干细胞移植。结果 :移植过程顺利 ,+ 10天～ + 14天中性粒细胞 >0 .5× 10 9/ L。 + 14天～ + 2 1天血象和骨髓象达 CR。 3例均达嵌合性植入。无移植物抗宿主病。 2例随访 116 d仍健在。 1例 + 5 6 d移植排斥及白血病复发。结论 :非清除性异基因干细胞移植简便、安全、并发症轻 ,对难治性急性白血病有较好疗效。
Objective: To investigate the role of non-destructive allogeneic stem cell transplantation in the treatment of refractory acute leukemia. Methods: Three cases of refractory acute leukemia were treated with cyclophosphamide, cyclophosphamide, cytarabine or anti-lymphocyte globulin for allogeneic peripheral blood stem cell transplantation. Results: The transplantation process was successful. The neutrophils were more than 0.5 × 10 9 / L from + 10 days to + 14 days. +14 days ~ +2 1 days blood and bone marrow up to CR. 3 cases reached chimeric implantation. No graft-versus-host disease. Two cases were still alive after 116 days of follow-up. A case of +5 6 d transplant rejection and relapse of leukemia. CONCLUSION: Non-destructive allogeneic stem cell transplantation is simple, safe and has light complications. It has a good curative effect on refractory acute leukemia.