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用放射免疫方法测定了３１名口腔粘膜扁平苔藓患者（女性１９名，男性１２名）经雷公藤总萜片治疗三个月前后其血浆中雌二醇（Ｅ＿２）及睾酮（Ｔ）的含量，结果显示：经雷公藤治疗后，女性患者血浆中已水平较治疗前明显升高，两者相差显著（Ｐ＞０．０５）；而男性患者的Ｅ＿２水平在治疗前后无明显差别（Ｐ＞０．０５）；同时，男、女患者血浆中Ｔ的含量在治疗前后亦无明显差异（Ｐ＞０．０５）。本研究结果提示：雷公藤对男、女ＯＬＰ患者血浆中Ｔ的含量影响不大，对男性患者体内Ｅ＿２水平有否调节作用尚须进一步研究；但它能升高女性患者血浆中已的含量，从而表明雷公藤制剂对女性ＯＬＰ患者的疗效除与其的免疫抑制及抗炎作用有关外，尚与其能调节患者体内Ｅ＿２的水平有一定关系。
The plasma levels of estradiol (E2) and testosterone (T) in 31 patients with oral mucosa lichen planus (19 females and 12 males) were measured by radioimmunoassay after three months treatment with Tripterygium total terpene tablets. The results showed that the plasma level of the female patients was significantly higher than that before treatment (P> 0.05), while there was no significant difference in the E_2 levels between male and female patients before and after treatment (P> 0 .05). At the same time, there was no significant difference in plasma T concentrations between male and female patients before and after treatment (P> 0.05). The results of this study suggest that triptolide has little effect on plasma T concentrations in male and female OLP patients, but whether it regulates the level of E 2 in male patients needs to be further studied; however, it can increase the content of plasma in female patients, Thus, the efficacy of Tripterygium preparations in female patients with OLP is not only related to its immunosuppressive and anti-inflammatory effects, but also to its regulation of E_2 level in patients.