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目的:通过检测尿中肾小球源性及肾小管源性蛋白尿了解类风湿关节炎患者肾脏损害情况。方法:用免疫速率散射比浊法检测44例类风湿关节炎患者晨尿微量白蛋白、免疫球蛋白G、α1-微球蛋白和β2-微球蛋白,并与46例骨性关节炎患者对照。结果:55%的类风湿关节炎患者尿微量蛋白阳性,肾小管源性蛋白尿较肾小球源性蛋白尿更多见。对照组有15%患者出现轻度蛋白尿,且有明确的肾损害因素。2组比较差异有统计学意义(P<0.05)。结论:类风湿关节炎患者肾损害较常见,联合检测多种尿微量蛋白有利于早期诊断。
OBJECTIVE: To investigate the renal damage in rheumatoid arthritis patients by detecting glomerular and renal tubular proteinuria in urine. Methods: Morning urine microalbumin, immunoglobulin G, α1-microglobulin and β2-microglobulin in 44 patients with rheumatoid arthritis were detected by the immune rate nephelometry and compared with 46 patients with osteoarthritis . Results: 55% of patients with rheumatoid arthritis were microalbuminuria, and renal tubular proteinuria was more common than glomerular proteinuria. Control group, 15% of patients with mild proteinuria, and there are clear factors of renal damage. The difference between the two groups was statistically significant (P <0.05). Conclusion: Renal damage is more common in patients with rheumatoid arthritis. Combined detection of various urinary microalbumin is helpful for early diagnosis.